By Mark D. Rothmann,Rothmann
ISBN-10: 1584888040
ISBN-13: 9781584888048
The elevated use of non-inferiority research has been observed by way of a proliferation of analysis at the layout and research of non-inferiority stories. utilizing examples from actual medical trials, Design and research of Non-Inferiority Trials brings jointly this physique of study and confronts the problems keen on the layout of a non-inferiority trial. each one bankruptcy starts with a non-technical advent, making the textual content simply understood through these with out previous wisdom of this kind of trial.
Topics lined include:
- A number of problems with non-inferiority trials, together with a number of comparisons, lacking info, research inhabitants, using safeguard margins, the interior consistency of non-inferiority inference, using surrogate endpoints, trial tracking, and equivalence trials
- Specific concerns and research equipment while the information are binary, non-stop, and time-to-event
- The historical past of non-inferiority trials and the layout and behavior issues for a non-inferiority trial
- The power of facts of an efficacy discovering and the way to judge the influence measurement of an energetic keep an eye on therapy
A complete dialogue at the objective and concerns concerned with non-inferiority trials, Design and research of Non-inferiority Trials will help present and destiny scientists and statisticians at the optimum layout of non-inferiority trials and in assessing the standard of non-inferiority comparisons performed in practice.
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Design and Analysis of Non-Inferiority Trials (Chapman & Hall/CRC Biostatistics Series) by Mark D. Rothmann,Rothmann
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