High-Throughput Screening Methods in Toxicity Testing by Pablo Steinberg PDF

Explores the advantages and barriers of the most recent high-throughput screening methods

With its specialist assurance of high-throughput in vitro screening tools for toxicity checking out, this booklet allows researchers to speed up and streamline the overview and threat evaluate of chemical compounds and medication for toxicity. in addition, it permits them to conform with the newest criteria set forth by means of the U.S. nationwide study Council's "Toxicity checking out within the twenty first Century: A imaginative and prescient and procedure" and the E.U.'s achieve laws. Readers will find a number of state-of-the-science, high-throughput screening equipment awarded through a gaggle of best specialists in toxicology and toxicity testing.

High-Throughput Screening equipment in Toxicity Testing is split into 5 parts:

• General points, together with predicting the toxicity strength of chemical substances and medicine through high-throughput bioactivity profiling
• Assessing diverse cytotoxicity endpoints
• Assessing DNA harm and carcinogenesis
• Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity
• Assessing drug metabolism and receptor-related toxicity

Each bankruptcy describes strategy rules and contains precise information regarding information new release, info research, and purposes in chance review. The authors not just enumerate the benefits of every one high-throughput strategy over similar traditional tools, but in addition indicate the high-throughput method's obstacles and capability pitfalls. moreover, the authors describe present study efforts to make high-throughput toxicity screening much more low cost and streamlined.

Throughout the publication, readers will locate lots of figures and illustrations to assist them comprehend and practice the newest high-throughput toxicity screening methods.

This e-book is perfect for toxicologists and different researchers who have to enforce high-throughput screening equipment for toxicity trying out of their laboratories in addition to for researchers who have to overview the knowledge generated via those methods.