Download e-book for kindle: Physiologically Based Pharmacokinetic Modeling: Science and by Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J.

By Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III

ISBN-10: 0471478148

ISBN-13: 9780471478140

A definitive, unmarried resource of knowledge on PBPK modeling
Physiologically-based pharmacokinetic (PBPK) modeling is changing into more and more vital in human overall healthiness possibility checks and in assisting pharmacodynamic modeling for poisonous responses. prepared by means of periods of compounds and modeling reasons so clients can quick entry info, this can be the 1st finished reference of its kind.
This booklet provides an summary of the underlying ideas of PBPK version improvement. Then it presents a compendium of PBPK modeling info, together with historic improvement, particular modeling demanding situations, and present practices for:
* Halogenated Alkanes
* Halogenated Alkenes
* Alkene and fragrant Compounds
* Reactive Vapors within the Nasal Cavity
* Alkanes, Oxyhydrocarbons, and similar Compounds
* insecticides and protracted natural Pollutants
* Dioxin and similar Compounds
* Metals and Inorganic Compounds
* Drugs
* Antineoplastic Agents
* Perinatal Transfer
* Mixtures
* Dermal publicity Models
as well as pinpointing particular details, readers can discover diversified modeling ideas and purposes. An authoritative reference for toxicologists, ecotoxicologists, threat assessors, regulators, pharmacologists, pharmacists, and graduate scholars in pharmacokinetics and toxicology, Physiologically-Based Pharmacokinetic Modeling compiles info from leaders within the box and discusses destiny instructions for PBPK modeling.

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Physiologically Based Pharmacokinetic Modeling: Science and Applications by Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III


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