By Ernest Giralt,Mark Peczuh,Xavier Salvatella
ISBN-10: 0470059052
ISBN-13: 9780470059050
Protein floor Recognition offers an in depth therapy of this technique, with themes including:
- an prolonged survey of protein-protein interactions which are key avid gamers in human sickness and biology and the potential of therapeutics derived from this new perspective
- the basic actual concerns that encompass protein-protein interactions that needs to be thought of while designing ligands for protein surfaces
- examples of protein surface-small molecule interactions, together with remedies of protein-natural product interactions, protein-interface peptides, and rational techniques to protein floor reputation from version to organic systems
- a survey of thoughts that would be necessary to the invention of recent small molecule protein floor binders, from excessive throughput synthesis and screening ideas to in silico and in vitro tools for the invention of novel protein ligands.
Protein floor Recognition offers an highbrow “tool-kit” for investigators in medicinal and bioorganic chemistry trying to take advantage of this rising paradigm in drug discovery.
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Protein Surface Recognition: Approaches for Drug Discovery by Ernest Giralt,Mark Peczuh,Xavier Salvatella
by Christopher
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